Chronic renal failure is a clinical condition characterized by irreversible decline in renal function and is always associated with a progressive decrease in GFR (Glomerulo Filtration Rate). The condition of patients with chronic diseases is often found to have psychological disorders. Psychological disorders that are not handled properly in patients with chronic diseases will aggravate the pain and reduce the quality of life. The purpose of the study was to analyze the effect of length illness and stadium on stress levels with the impact on quality of life in chronic renal failure patients. The research method used was crosssectional analytic with respondents totaling 92 patients with chronic renal failure and were taken using accidental sampling method. Data collection tools for length of illness and stadium using a questionnaire, stress levels using the DASS scale and the WHOQOL-BREF quality of life scale. Analysis using path regression analysis. The results showed that there was an effect of length of illness and stadium on the stress level of patients with chronic renal failure with their respective significance values, namely length of illness (0.002) and stadium (0.000). The length of illness, stadium and stress level affect the quality of life of patients with chronic renal failure with their respective significance values, namely length of illness (0.002), stadium (0.000), and stress level (0.000). The length of illness through stress levels has an influence on the quality of life of patients with chronic renal failure with a direct effect (-0.272) and an indirect effect (-0.188). Stadium through stress levels has an influence on the quality of life of patients with chronic renal failure with a direct effect (-0.318) and an indirect effect (-0.095). The conclusion is that the longer a patient experiences chronic renal failure with a higher stadium, the heavier the stress level and the lower the quality of life. Therefore, in addition to focusing on physical therapy, it is also important to teach relaxation techniques so that sufferers can cope with the stress that comes from their illness.