Abstract: Background: This study aims to determine the effect of giving moringa oleifera leaves extract plus royal jelly supplement on increasing erythrocyte index in anaemia pregnant women. The method of the research: The research method used is randomized controlled design. The research was conducted in Polongbangkeng Utara Sub district (Puskesmas Polongbangkeng Utara, Ko'mara and Towata) Takalar Regency with a Haematology Analyze examination at the Clinical Pathology Laboratory of the UNHAS Hospital. Subject of the study is 63 anemia pregnant women consisting of 21 subjects of Moringa Leaf Extract plus Royal Jelly (MLERJ) group with the intervention of 1 capsule in the morning with a dose of 500 mg MLE + 10 mg RJ, 21 subjects of Moringa Leaf Extract (MLE) with the intervention 1 capsule in the morning with a dose of 500mg MLE and the Placebo group 21 subjects with the intervention 1 placebo capsule in the morning with a dose of 500mg starch flour, where all of the subjects consumed Fe tablets at night with a dose of 1x60mg. Data were analyzed using the Chi-Square, Mann-Whitney, Wilcoxon, Paied T-Test, Kruskal-Wallis and PostHoc Mann Whitney tests. Results: Based on the characteristics of research subjects based on age, education, occupation, income and parity, the three research groups were not different or evenly distributed. The results showed an increase in the erythrocyte index levels (MCV, MCH and MCHC) of the three study groups. Where in the MLERJ group the levels of MCV, MCH and MCHC experienced a significant increase, in the MLE group who experienced a significant increase in MCV and MCHC levels, while in the Placebo group who experienced a significant increase only in MCV levels. Conclusion: Supplementation Moringa Leaf Extract Plus Royal Jelly is more effective at increasing the erythrocyte index levels (MCV, MCH and MCHC) in anemic pregnant women so that it can be used as an alternative treatment to treat anemia.