BACKGROUND: During exercise we release a lot of hormones and neurotransmitters. Dopamine is one among the hormones which is released in several parts of the mid brain during exercise. It is said that exercise can help to avoid many diseases and even cancer.. In 2020 the number of cases diagnosed were 104,610 all around the world .In this study we analysed the role of endogenous dopamine replica over gene expression of Apoptotic and tumor suppressor gene against colon cancer prevention.