Anemia is a disease that involves red blood cells characterized by a decrease in erythrocyte mass where red blood cells function as hemoglobin carriers. This study aims to determine the effect of the combination of dates syrup (Phoenix Dactylifera) and bee pollen on Erythrocyte index and birth weight of Wistar white rats (Rattus Norvegiccus). The method in this research was experimental lab and research design was randomized post test control group only design on the variable value of erythrocyte index and birth weight of white wistar rats. The research was conducted in August - September 2020 at the Hasanuddin University Biopharmaceutical Laboratory. The samples in this study were 28 pregnant wistar rats divided into 4 groups, namely the CMC (control) group, bee pollen syrup, date syrup and the group with the combination of syrup each consisting of 7 samples. The intervention was carried out for 21 days with a dose ratio of 20 g of dates (equivalent to 5 dates) and 1 g of bee pollen given orally using a sonde with a dose of 20 ml / 150-200g / body weight / day. Data analysis on erythrocyte index used paired sample Ttest and repeated anova test while weight data analysis used the Kruskal Wallis test with repeated man whitney. Results The erythrocyte index level and body weight of the puppies after the intervention had the highest increase, namely in the combination syrup group with parameters of MCHC erythrocyte levels with a significant value of p = 0.013 which means <0.05 compared to the CMC (Control) group, bee pollen syrup and date syrup increased evenly.