Dates and bee pollen contain of bioactive compounds in the form of flavonoids, polyphenols, magnesium, carbohydrates, proteins, and fats which allow them to affect blood glucose levels and weight gain. This study aims to determine the effect of the combination syrup of date and bee pollen on blood glucose levels and weight gain of pregnant Wistar rats. The combination of date and bee pollen syrup is made of 20.6% w/v of dates and 1.035% w/v of bee pollen in 100 ml of syrup. Then the rats were divided into 4 groups, namely the CMC solution as a control group, date syrup with a dose of 413.2 mg/200 g of rats’ weight, bee pollen syrup at a dose of 20.7 mg/200 g of rats’ weight and combination syrup of dates and bee pollen at a dose of 413.2 mg dates and 20.7 mg bee pollen /200 g BW of rats as the intervention group which were given for 20 days. Furthermore, the examination was carried out 3 times, on day 0, day 13, and day 20. The average of blood glucose levels after the intervention was 87.29 g/dl in the control group, date syrup 78.14 g/dl, bee pollen syrup 84.14 g/dl and the combination syrup 83.29 g/dl, while the average of body weight was 240.57 in the control group, 256.86 date syrup, 244.14 bee pollen syrup, and 265.00 for combination syrup. The results of statistical analysis showed P>0.05, it means that there was no significant difference in the value of glucose levels among each group, but there was a significant difference in the body weight of rats in which P<0.05, so the combination syrup of date and bee pollen is safe to be consumed by pregnant women because it does not affect the blood glucose levels significantly and it can increase their weight.