Aim: comparison of Ultrasonography (USG) and Computed Tomography (CT) in the evaluation of suspicious Ovarian Masses. Methods: This prospective observational study was carried out in the Department of Radiodiagnosis, Indira Gandhi Institute of Medical science, Patna, Bihar, India, for 1 year. All patients underwent abdominal Ultrasonography and CT scan with determination of the ovarian mass characteristics. Results: The Mean age of the patients was 41.94 years. 35.83% belong to 40-50 year age group and followed by 30-40 years 21.67%. There were total 69 cases of Pre-menopausal stage and 51 cases of Post-menopausal stage having ovarian cyst. Out of 69 cases of Premenopausal conditions have 15 number of malignant and 54 number of benign type of mass. In the Postmenopausal group there are 37 cases of malignant and 14 cases of benign ovarian mass was observed. Table 3 shows CT and USG comparison for the diagnosis of ovarian masses. Overall, CT was found to have 97.5% sensitivity, 90.83% specificity, and an accuracy of 95% in the differentiation of benign and malignant ovarian masses, while PPV and NPV were 96.67% and 91.67%, respectively. The sensitivity of USG was 87.5%, specificity was 85.83% and PPV and NPV were 86.67% and 82.5% respectively. Conclusion: Significant differences were in the two methods i.e USG and CT. CT was showed more advantages regarding tumor localization, characterization. Hence CT could advise if the unusual abnormalities were observed in routine USG scan in the diagnosis of ovarian masses.