The sudden life change causes diabetes mellitus (DM) patients to show some negative psychological reactions, therefore, the self-care, locus of control, and self-esteem become important for diabetic patients as a control towards their disease. The study aimed to analyze the correlation between self-esteem and locus of control with the self-care ability of DM type 2 patients. The study was the correlation with 122 samples of DM type 2 patients. Data analysis applied is the Pearson correlation coefficient, t-independent test, and multiple linear regressions. The result shows that there was a correlation between selfesteem and self-care ability with the correlation coefficient of 0.777 (p-value 0.000, α: 0.05). There was a correlation between locus of control and self-care ability with a correlation coefficient of 0.665 (p-value 0.001, α: 0.05). Data were analyzed by multiple linear regressions. There was a correlation between self-esteem with respondents' self-care ability after controlled by education variable, marital status, and profession (B = 0.266, SE=0.32). There was a correlation between locus of control with self-care ability (B=0.147, B=0.37). It was concluded that the most dominant variable which affects self-care ability was selfesteem.