Bronchiolitis, a lower respiratory tract disorder is most commonly caused by respiratory syncytial virus (RSV) infection. Acute bronchiolitis has become one of the major cause of hospitalization in infants. Management of acute bronchiolitis is mainly supportive therapy, though the various modalities of supportive therapy are upcoming effectiveness is unclear. This study is done to know the effectiveness of combined adrenaline nebulization with injection dexamethasone versus 3% NS (Normal saline) nebulization in acute bronchiolitis. Various modalities for management of acute bronchiolitis is on trials with the preliminary evidences for combination of various therapies in comparison with the novel therapy hypertonic saline nebulization. A synergism with adrenaline and steroids combination was found effective and encouraging in management of acute bronchiolitis. A hospital based simple randomized control study was carried out among 200 cases of acute bronchiolitis with 2 groups, combined nebulized adrenaline with injection dexamethasone and 3% NS nebulization group each carrying 100 cases. Among 200 participants of acute bronchiolitis. There is reduction in the duration of the hospital stay in adrenaline nebulization with injection dexamethasone (4.58 ± 0.85).