Abstract: BACKGROUND: The use of computers in Medical education has been in continuous development since the early 1960s. Its adoption however, has been limited. E-learning can be defined as the use of information and communications technologies (ICT) or the Inter and intranet in educational activities. Evaluation of perceptions about E-learning as a method of teaching and learning was needed in College of Medicine and Dentistry, so that E learning methods could be applied assisting students and faculty in increasing their knowledge and skills to ensure competent performance, better patient care and enhanced community services. AIM: The aim of the study was to evaluate the perception of E-learning methods amongst Medical and Dental students as well as faculty of Jouf University. The objectives of the study were assessment of participants’ knowledge and vision about E-learning as well as their preferred Elearning method. METHODOLOGY: Cross-sectional study was carried out using a structured questionnaire involving students and faculty members of College of Medicine and Dentistry registered in the year 2018-2019. Sample size was 256 data was collected after approval from LCBE, via convenience sampling. Analysis was done on SPSS. RESULTS: 90% of the participants agreed that they understood the term E-learning and 83% agreed that incorporating E learning in the college was useful However, they don’t see E-learning as replacing the traditional method rather most of the participants suggested a blended learning system with more active involvement of activities via the Black Board and improvement of PBL and TBL rooms. CONCLUSION: Our results show that almost two thirds of the faculty members and students agree that E-learning methods are, more flexible, can provide more comprehensive information, can improve PBL and TBL sessions. It is time saving, eco-friendly and supports the students various learning styles.