We aimed to investigate that whether intraoperative intravenous aminophylline is effective for prevention of postdural puncture headache after caesarean section or not. The study included patients over the age of 18 years. Anesthesia conversion to general anesthesia was required if the spinal anesthesia failed. The demographic data of the patients (age, weight, height, and physical status), comorbid diseases, intraoperative intravenous aminophylline use, as well as the number of spinal puncture attempts and presence of postdural puncture headache were collected. There were 75 records in total (40 in the aminophylline group and 35 in the control group) of patients who met the inclusion criteria. 15 percent of the aminophylline group (n=6) and 13 percent of the control group (n=9) developed postdural puncture headache. Postdural puncture headache frequency and number of attempts did not differ between groups (p>0.05), nor did age, body weight, height, Society of Anesthesiologists physical status, and comorbid diseases. The use of intravenous aminophylline during spinal anesthesia performance was not associated with postdural puncture headache occurrence (p>0.05). Postdural puncture headache incidence following caesarean section was not affected by intraoperative intravenous aminophylline administered during spinal anesthesia.