Abstract Asthma is an infectious condition which is heterogeneous and characterized by enhanced airway hyper response to external stimuli including irritants. Asthmatics could be more prone to environmental irritants than healthy citizens, that is, to react in lower quantities. The study also checked the empirical assistance for this speculation and analysed in what manner asthma is taken into consideration when establishing dosage limits and guideline values. The study found that experiments compared stable and asthmatic people are sometimes inconclusive. However, the available reports are underused by business and specialist committees respectively. Data for certain irritants show that asthmatics are three times more responsive than safe. The most plentiful data on sulphur dioxide found. A benchmark concentration study here showed a 9-fold intensity gap. Based on such results, when establishing exposure limits and recommendations for irritants a default measurement factor is recommended.