ABSTRACT The hexahydroacridne derivatives was synthesised and characterised by various techniques. Nuclear Magnetic Resonance (NMR) spectroscopy is a well established technique for providing information about structural diagnosis of organic molecule and mass spectrometry. Optical properties of hexahydroacridine derivatives, has been made by experimentally. Synthezied hexahydroacridine derivatives were screened for antioxidant, anti inflammation, and anti diabetic activity. The compounds were screened for their Antioxidant activity was evaluated by DPPH radical scavenging method and compared with standard ascorbic acid. Anti inflammation activity were examined by albumin denatuation and compared with standard aspine. Antidiabetic activity against α-amylase enzyme and compared with standard drug acarbose.