Abstract: The study was aimed to compare between two medication regimens in treatment of nocturnal enuresis in children older than 15 year and young adult . A study was conducted on 48 children suffering from nocturnal enuresis, divided into two groups, the first group included 25 children treated with tricyclic antidepressant (TCAD) in combination with loxoprofen tab. The second group included 23 child treated with TCAD alone. Our results showed significant preference to group I ( loxoprofen and TCAD ) as compared with group II (TCAD alone ) in treatment of nocturnal enuresis after 1-3WK and 3-6WK respectively. From this study we can conclude that loxoprofen plus TCAD could reduce number of NE significantly as compared with TCAD alone.