Osteosynthesis with open reduction technique in comminuted fracture has several disadvantages like increase rate of non-union, non-healing of soft tissue, infection and failure of implant. These problems can be managed by percutaneous minimally invasive plating technique which preserve the vascularity and soft tissue anatomy of fracture fragments. A total of 40 patients were involved in this study. Distal tibia with or without fibula fracture (12), Diaphyseal tibia (10), Proximal tibia (8), Supra condylar Femur (6) and Subtrochanteric Femur (4) were operated by using the principles of indirect reduction and biological fixation with plates under C-arm guidance. Weight bearing was allowed according to the clinical and radiological union at follow up.