ABSTRACT: Superior orbital fissure syndrome is a complex of cranial nerve impairment that affects the CN III, IV, V and VI all of which enters the orbit through the superior orbital fissure. Superior Orbital fissure syndrome occurs as a result of compression of all or some of these nerves passing through the fissure. Three major factors contributing to the syndrome includes traumatic injury, neoplasm and inflammation. This article takes into account the various data previously reported in literature and aims at providing a detailed knowledge about the anatomy of the superior orbital fissure to provide a better understanding about the syndrome.