One of the global public health diseases is the hepatitis C. It is widely distributed and primarily begin with acute infection. Some of them spontaneously clear the virus by their immune system. However, more than half of HCV infected individuals will develop their infection to chronic. No effective vaccine has been discovered against HCV until know. In most patients with 8-12 weeks of all oral drug regimens, direct-acting antiviral treatment will result in a virologic cure. Since the virus targets the immune system, study of KIR genes is involved in this research. Detection on these genes conducted by qPCR technique. This work aimed to detect KIR genotypes in patients with HCV compared with healthy subjects and to find out the effect of each gene as an indicator of the decline or progression of the infection. The results showed BX genotype was more frequent in patients, KIR2DL4 and KIR2DL5 genes were frequent in patients more than in control. However, KIR2DL1, KIR2DS2, KIR2DS3, KIR3DL2, KIR2DS1, KIR2DS4 and KIR2DL5 were significantly frequent in patients with HCV (RNA+). In conclusions; genes of KIR2DL1, KIR2DS2, KIR2DS3, KIR3DL2, KIR2DS1, KIR2DS4 and KIR2DL5 considered as risk factors for persistent and leading to the late infection.