Background: High blood pressure or Hypertension is a very serious problem now a days. Directly intake of sodium in the form of sodium salt helping to trigger prevalence of hypertension, at the same time intake of potassium decreasing the blood pressure level. Aim and Objective: Present study aimed to study the association between 24 hours urinary sodium and Potassium excretion and blood pressure in patients with primary hypertension. Material and Methods: This randomized prospective study conducted between May 2019 and July 2020, in which each of 30 patients with hypertensive and non-hypertensive admitted to Department of General Medicine, MNR Medical College and Hospital, Sangareddy, as per the as per JNC VI report-BP – 140/90 mmHg least at three different occasions after refraining from anti-hypertensives and diuretics included in the study and blood pressure, biochemical parameters in the blood, anthropometric measurements, and 24-hour urine samples were obtained. Data was collected and analyzed by statistical software SPSS V 25. Result: Total population of 60 patients aged between 18 to 75 years distributed between cases and control as per the criteria. Average age of the patients were 49.45 ± 8.91 Years. The overall mean sodium and potassium excretion was 164.70 ± 18.85 mmol/day) and 53.68 ± 7.78 mmol/day, respectively. The average ratio of systolic/diastolic blood pressure was 139.47 ± 25.89/87.40 ± 11.12 mmHg. Age, gender, BMI and serum cholesterol had significant influence on 24 hour urinary sodium excretion. Urinary sodium was positively significant correlated with systolic and diastolic blood pressure. Present study showed that SBP and DBP were significantly associated with sodium intake among primary hypertensive and showed inversely associated with potassium. These associations were mainly driven by the hypertensive group. Conclusion: From overall analysis study conclude that in order to decline the prevalence of essential hypertension and resist to go at hypertensive crisis stage, reduction in salt intake for long term would be beneficial and also morbidity and mortality due to cardiovascular disease and stroke can be reduced.