This study was conducted in 2019-2020 for the purpose of determining the histopathological effects of sodium benzoate on the liver and kidneys and the effects on the level of enzymes for ALT and AST, where twelve rabbit eggs were used. Where the animals were divided randomly into three groups, namely: the control group: - which includes four rabbits and the first treatment group N1 (oral dose with sodium benzoate at a concentration of 100 mg / kg of body weight) and the second treatment group N2 (oral dose of sodium benzoate at a concentration of 200 mg / (Kg), where the totals were dosed orally daily for a period of 30 days. The animals were killed after the end of the experiment and then the liver and kidneys were removed for the purpose of conducting a study of the changes in them. These changes appeared in the liver tissue represented by the presence of hemorrhage and lymphocyte infiltration with the rupture of the cells lining the central vein, and there were also a few cases of karyolysis with the presence of some nuclei that Small size and condensation suffered by Pyknotic Nuclei. In the kidney tissues, the histological lesions were represented by a general necrosis of the tissue, Necrosis and Vacuolated Necrosis, with the presence of degeneration within a section of the glomeruli within the cells that made it, with the observation of dense and small nuclei, which is on the way to death. As for the enzymatic effects, the results of the statistical analysis indicated the presence of significant differences (P <0.05), the level of ALT and AST enzymes between the two concentrations of sodium benzoate when compared, while the level of enzymes increased significantly (P <0.05) with increasing concentration.