yurved is science of healthy life, which has its unique and useful basic concepts. Out of these concepts, Avedhyasira and Marma-Vigyan are important structural concepts which are described by AcharyaSushrutin SushrutaSamhitaSharirsthan and by AcharyaVagbhat in AstangHridayaSharirsthan. Without studying Avedhyasira and Marma, Surgeon cannot perform skilled and perfect surgery as well as for physician it will be definitely difficult to treat the patients without knowing the perfect location of these structures. In our present study we emphasized on Avedhyasira and Marmain the head region. Specially Adhipati and Shankhathese two structures which are studying in the text as Marma and Avedhyasira are the same, which in the modern texts are given as vital parts. With the help of correlation with modern anatomy, here we try to explain exact anatomicalstructure mentioned as Adhipati and ShankhaAvedhyasiraand sadhyapranharMarma. In ancient time AcharyaSushrut and Vagbhat have clearly mentioned these structures from which incision should not be taken and more care should be taken as they are vital parts and fatal of life. Injury to these structures may cause death also.