Abstract Aim: The aim of the present study is to study the Preformulation parameters of Ganciclovir (GCR) for the preparation of SDs of GCR was prepared by microwave fusion method in upcoming study. Material & Methods: Preformulation study i.e. solubility, assay, melting point, drug excipient compatibility study, DSC, FT-IR and various parameters for pre compression of flow property were measured. Results: The Organoleptic properties of pure Ganciclovir (GCR) were physically studied and it was found in the powder form. The color of the drug was found to be white to light yellow with characteristic odour and slightly bitter taste. GCR showed a sharp melting point at 136.5±0.5oC. The solubility of these was found to have solubility <0.3 µg/mL in indicating the very poor solubility of the drugs selected. The Calibration curve for GCR represents slope (y) = 0.0901x+0.0536 with regression (R2 ) value of 0.9990, indicates the linearity. The Hygroscopic data of GCR revealed that the drugs are non-hygroscopic as the % weight upsurge was <0.2%. The thermogram of GCR was characterized by single sharp endotherm at 137.29oC (indicates its melting). The DSC thermogram of the drug was observed to be in contract with the specifications. Conclusion: The main theme behind this research work was to prepare GCR SDs using PEG bases (PEG3350, PEG 4000, PEG6000, PEG8000 and PEG20000), PVP bases (PVP K-12, PVP K-17, PVP K-25, PVP K-30 and PVP K-90), Poloxamers (Poloxamer 108, Poloxamer 188, Poloxamer 237, Poloxamer 338, Poloxamer 407) and Urea.