Background: Normal kidney secretes nitrogenous waste product, regulate volume and acid /base balance of plasma and synthesize erythropoietin, 25-(OH)2- cholecalciferol and renin. Chronic kidney disease (CKD) is caused by a progressive and irreversible decline in the number of nephrons. A wide variety of oral manifestations occurs in CKD patients. Determination and identification of these manifestations will improve the quality of life in these patients. Methods: Thus, this cross-sectional study was conducted in the Department of Medicine, Sanjay Gandhi Memorial Hospital (SGMH), associated with Shyam Shah Medical College (SSMC), Rewa, in the Vindhya region between February 2019 and August 2020. Results: Out of 127 patients, maximum prevalence of oral manifestations occurring was pallor (93.70%), xerostomia (84.25%), halitosis (72.44%), sore throat (64.56%), lip pigmentation (63.77%), periodontitis (48.81%). High Urea levels were found to be highly significant when correlated with halitosis (p<0.00052). Xerostomia was found significant when correlated with duration of dialysis (<1 year) with p<0.032. Conclusions: Manifestations of CKD are common during the progression of uremia. In the patients studied, the impact of CKD on the oral cavity was evidenced by significant changes, which pointed to an inter-relationship between oral health and CKD.