INTRODUCTION: The major causes of cancer and death from kidney failure among males worldwide are tobacco consumption such as smoking and chewing. Excessive morbidity and mortality from a number of diseases are associated with smoking. In cross-sectional studies and in selected population samples, the link between cigarette smoke and albuminuria has already been seen. In Caucasian populations with type 1 and type 2 diabetes, it has been shown that cigarette smoking raises the risk of microalbuminuria. Therefore, the purpose of the current study was to determine microproteinuria and other renal functions in smokers and to determine whether smoking is associated with an increased risk of renal disease. Material and Methods: The present study included 100 subjects of age group 35-55 years. Out which 75 were cigarette smokers and 25 were normal healthy control. Microalbuminuria was estimated by biochemistry fully auto-analyzer.This study is based in part on secondary data from a cross-sectional analysis of this study population that has been presented in detail previously. Results:In the current study, relative to non-smokers, we observed substantial increased levels of urinary albumin and urinary albumin creatinine ratio in cigarette smokers. The level of microalbuminuria and urinary albumin creatinine ratio was directly linked to smoking levels. Among smokers, 55 had microalbuminuria (> 20 mg / L) and 45 had an increased ratio of creatinine to urinary albumin. The level of urea, creatinine, creatinine clearance was comparable. Conclusion: The creatinine ratio of urine albumin and urinary albumin is directly linked to the amount of cigarettes smoked each day. Smokers have a 4-fold higher microalbuminuria rate than nonsmokers.