Abstract: Background: One of the major causes of adverse Fetomaternal outcomes have been found to be the various Placenta mediated pregnancy Complications (PMCs). There are inconsistent studies that confirms or proves elevated Serum Homocysteine concentration to be one of the risk factors for Placenta Mediated Complications. Prospective and sufficiently powered studies that uses the pathophysiology of the disease as the basis of their study will help and encourage for a better management of women and fetuses at risk. Hence, this study focuses to determine whether elevated maternal plasma Homocysteine levels in early to mid-second trimester has any significant difference on the occurrence of Placenta-Mediated Complications (PMCs). Objectives: To study and compare the occurrence of Placenta mediated Complications and their Fetomaternal Outcome in women having normal and elevated Serum Homocysteine levels. Methodology: Females in their early second trimester (Gestational age within 12 -20 weeks) with singleton pregnancy irrespective of taking or not taking periconceptional folic acid, presenting for prenatal care in the ANC clinic or planning to deliver at AVBRH Hospital will be selected. Fasting Blood samples will be taken in EDTA Vacutainer tubes and transported to the laboratory within 30min and then the maternal Serum Homocysteine levels will be estimated using the Enzyme-Linked Immunosorbent Assay. Women with raise Plasma Homocysteine Levels will be categorized into Group A and women with Normal Plasma Homocysteine Levels will be categorized into Group B. Pregnancy outcomes and complications will be extracted by studying the antenatal, perinatal, and postnatal medical records and comparison will be made between both the groups for the level of significance. Results: The Expected Outcome of this study will be a significant difference in the occurrence of Placenta Mediated Complications and related Adverse Fetomaternal Outcomes in women having elevated and normal Serum Homocysteine Levels. Conclusion: Our Study will prove the role of maternal homocysteine levels in occurrence of Placenta-mediated pregnancy Complications.