Background:Corona virus disease 2019 (COVID 19), caused by the novel corona virus is a rapidly spreading and devastating infection which has become a global pandemic. The present study assessed the severity of disease in Covid-19 positive patients. Aims and objective: To study the different haematological parameters and infection biomarkers in COVID-19 patients. To evaluate the role of hematological parameters in determination of COVID-19 disease severity. Materials & Methods: 600 Adult (age >18 years old) patients who were diagnosed with COVID‐ 19 according to WHO interim guidance were screened, between Feb 2020 and Feb 2021 (one year). Data of complete hematological parameter and infection biomarker was collected from records of Central Pathology Lab at Bundelkhand Medical College Sagar, M.P., India. Results: Out of 600 patients, males were 380 and females were 220. Out of 600 patients, 540 survived and 60 died. There was significant difference in value of Hb, TLC, ANC, NLR, PLT, MCV, RDW, PT, aPTT, D- Dimer, Ferritin and CRP level in patients admitted in ward, HDU, ICU, between genders and those survived and died. Conclusion:The study concluded that leukocytosis, neutrophilia, elevated Neutrophil to lymphocyte ratio, APTT, D- Dimer, serum ferritin, CRP and RDW-SDassociated with severity of covid-19 disease.