Background: Galeazzi fracture is the fracture of middle to DISTAL third of Radial shaft associated with disruption or subluxation of distal radio ulnar joint [DRUJ]. This injury was described 1st by Astley Cooper in 1826 and later named after Riccardo Galeazzi who published his series of cases in 1934 and has been termed as a fracture of necessity and treated with open reduction internak fixation [ORIF] with compression plates with or without pinning of DRUJ. Objectives: The purpose of our study is to study the functional outcome of DRUJ instability in patients with Galeazzi fractures treated with transfixing K wire for DRUJ instability. Materials and Methods: 23 patients of Galeazzi fracture treated with transfixation with K wire for DRUJ stabilization after stabilizing radius fracture at MMCRI Mysore from September 2020 to November 2022 with age between 18 to 70 years. Functional outcome for DRUJ instability were performed at 3 months after surgery and results were analysed by using QUICK DASH score. Results: 23 patients with Galeazzi fracture were followed up in this study, 23 patients were treated with K wire transfixation for DRUJ stabilization after fixing Radius fracture. Patients followed up at 6 weeks for removal of K wire applied for DRUJ stabilization. Functional outcome of DRUJ stability measured at 3 months after surgery with range of movements of writs joint and QUICK DASH score 95.6% of patients had good functional outcome. Conclusion: This study showed that Galeazzi fracture patients treated with open reduction of Radius fracture followed by transfixing K wire for DRUJ instability had good functional outcome results.