Background: The incidence of PMB is 10% in general population. At least 10-25% of PMB is said to have neoplastic lesions out of which approximately 10-15% are associated with endometrial carcinoma.The causes of post- menopausal bleeding can also be benign like atrophic endometrium, endometrial hyperplasia and polyps. The objective of this study was to evaluate endometrial pathology in women with post-menopausal bleeding to rule out endometrial cancer or atypical hyperplasia. Method and observations -This was a descriptive study done on73 post- menopausal women attending gynaecology OPD . TVS and Hysteroscopy was done and biopsy was taken from 50 high risk cases by D&C for HPE. Descriptive statistics was applied to collected data. The commonest pathological lesion was endometrial atrophy [42% cases] followed by hyperplasia in 20% cases and endometrial carcinoma in only 2% cases.Majority of patients presenting with PMB were less than 55 years of age. Sensitivity and specificity of histopathology in diagnosing endometrial lesions was 98.45% and 100%, respectively. Conclusion -Histopathological examination of endometrial biopsy specimens on D&C is highly sensitive and specific for diagnosis of endometrial lesions in patients with post-menopausal bleeding.