Abstract. The results of the study of the distribution frequency of the genotypes of the polymorphism of the rs1800629 TNF-α gene involved in the formation and clinical course of rosacea are revealed, which allows us to predict the development, course of the disease and to develop the optimal scheme for its prevention and treatment. We studied the polymorphism of the rs1800629 TNF-α gene in rosacea patients and determined the effectiveness of therapy depending on the severity and frequency distribution of genotypes.