Background: The incidence of Chronic Kidney Disease Stage-V and dialysis population requiring renal transplantation is increasing globally. Present study was aimed to evaluate the efficacy and safety of low dose continuous infusion of dexmedetomidine on hemodynamic changes, sedation and analgesic requirement intraoperatively and immediate postoperatively in patients undergoing for renal transplantation. Material and Methods: Present study was single-center, Randomized, prospective, double blind, placebo-controlled study, conducted patients, age between 18-60 years undergoing renal transplantation, ASA grade 2 and 3. Patients were assigned into 2 groups, as study Group (continuous infusion of dexmedetomidine at rate of 0.2 mcg/kg/h) & control Group.