India leads the world with largest number of diabetic population which is expected to rise around 69.9 million by 2025 unless urgent preventive steps are taken. Prolonged uncontrolled diabetes is associated with complications such as nephropathy, cardiovascular disease, retinopathy etc . Diabetic nephropathy is the largest single cause of end-stage renal disease. New pathways involved in the development and progression of diabetic kidney disease have been elucidated such as cystatin-C (a surrogate endogenous marker for estimating early decline in GFR in diabetes which can help to detect early kidney injury) and inflammatory markers including hs-CRP, TNF-α, IL-6 etc Aim : To evaluate the association of cystatin-C levels and Inflammatory marker( hs-CRP) in diabetic nephropathy patients of India with type-2 diabetes mellitus. Materials and Methods : A total of 150 samples from type-2 diabetes mellitus patients with diabetic nephropathy were collected from SBIMS hospital, Bhilai (C.G). Serum will be separated by centrifugation. Parameters will be estimated by the following methods- a) Estimation of serum cystatin-C by Immunoturbidimetry. b) Estimation of serum hs-CRP by ELISA kit method. Result and Observations : In the study out of 150 patients, 47 were females and 103 were males. All the patients having mean age of 53.16 ± 9.49 years. Mean Cystatin-C level among males was 2.85 ± 1.96. and that of in females was 2.44 ± 1.69. similarly Mean hs-CRP level among males was 8.10 ± 1.09 and that of in females was 7.47 ± 1.52. The correlation between Cystatin-C level and inflammatory marker hs-CRP was highly positively correlated among type 2-Diabetic Patients with Diabetic Nephropathy.