Background: During general anesthesia laryngoscopy, tracheal intubation and extubation are the critical events provoking transient, but marked sympathoadrenal response manifesting as hypertension and tachycardia. In addition, in laparoscopic surgery, CO2 is routinely used to create pneumoperitoneum, which causes increased plasma level of catecholamine and vasopressin. Aim & Objective: 1. To compare the hemodynamic changes- heart rate and mean arterial pressure. 2.To study the postoperative emergence and recovery.3. To study the postoperative nausea and vomiting incidence. Methods: Study design: Randomized comparative study. Study setting: Department of Anaesthesia, Kamineni Institute of Medical Sciences, Sreepuram Narketpally, India. Study duration: From January 2021 to January 2022 (1 year) Sample size: 56. Results: There was a statistically significant difference in mean SBP at pre operative of subjects between group (i.e, p=0.024). There was no statistically significant difference in mean SBP after bolus of subjects between group. There was a statistically significant difference in mean SBP At 2 hour of subjects between group (i.e, p=0.012). There was a statistically significant difference in mean DBP at pre operative of subjects between group. There was a statistically significant association between other side effects and group (p=0.033) and strength of association was 0.290. Conclusion: The addition of dexmedetomidine provides better hemodynamic stability