Background: The study of coagulation can be traced back to about 400 BC and to the father of Medicine, Hippocrates. The liver is the cornerstone of the coagulation system. The liver is the site of synthesis of fibrinogen and factors Ⅱ, Ⅴ, Ⅶ, Ⅸ, Ⅹ, Ⅺ and Ⅻ. Von Willebrand factor (VWF) is synthetized by the endothelium. When both cellular and plasmatic coagulation are defective, represents a hallmark of advanced liver disease. There is substantial overlap in the hemostatic abnormalities observed in the patients with acute infectious or toxic hepatitis, chronic hepatitis, and cirrhosis, the severity of hepatocellular dysfunction is typically more informative than the etiology