Background: This study was conducted to compare Clomiphene Citrate Vs Letrozole for ovulation induction in infertile PCOS women. Methods: This study includes 200 infertile PCOS women attending GOPD Department of Obstetrics and Gynaecology, NMCH from January 2021 to December 2022. The patients were divided in two groups. 100 women received 100mg CC once daily from D2-D6 of cycle. 100 women received 2.5 mg Letrozole once daily from D2-D6 of cycle – both groups for 3 cycles each. Follicular monitoring was done daily from D12-D16 of cycle. Inj HCG 5000IU was administrated IM when atleast one follicle with a mean diameter of more than equal to 18 mm was achieved. After 36 hours of HCG administration ovulation was confirmed on ultrasound. Results : Both groups were comparable with respect to age, BMI and mean duration of infertility. Both groups were compared with respect to number of follicles, mean diameter of largest follicle, rate of ovulation, mean endometrial thickness and serum progesterone level on D21 of cycle. The number of mature follicle was significantly lower but but the endometrial thickness and ovulation rate was significantly higher in Letrozole group than CC group. Conclusion: My study showed that Letrozole has better ovulation rate than CC and should be considered as 1st line drug for ovulation induction in infertile PCOS women.