Background: Accumulation of pericardial fluid (exudate, leaks, or blood) in the pericardial space in a quantity sufficient to cause serious obstruction to the inflow of blood to the ventricles results in cardiac tamponade. Present study was aimed to study clinico-etiological profile of patients with cardiac tamponade at a tertiary care center. Material and Methods: Present study was single-center, prospective, observational study, conducted in patients with cardiac tamponade diagnosed by clinical and echocardiography criteria and admitted to our hospital.