Despite advances, little is known about the epidemiology of interstitial lung disease (ILD). The aim of this study was to understand Clinical, Radiological, and functional Profile of ILD patients attending tertiary care center in Pune, India. Method: Prospective observational, study was conducted at Dr. D.Y. Patil Medical College, Hospital and Research, Pune. 50 known ILD patients, age 20 and above, who were attending OPD clinic and were willing to sign informed consent were recruited during July 2017 - September 2018. The information collected was age, gender, smoking habit, co-morbidities, symptoms, signs of ILD, ascultatory findings, area involved on auscultation, x-ray, CT scan and spirometer findings. Statistical analysis was done with mean, standard deviation, frequencies and percentages. Results: Among 50 ILD patients, there was male dominance (58% vs 42%). Average age was 58.02 ±14.66 years. Most common symptoms were cough (100%) and dyspnea (94%). Most common radiological finding was reticular (54%) and nodular (52%). No patients showed sputum +ve for AFB. Infra- axillary and interscapular area involvement (each) was observed in 82% patients. Restrictive pattern was most common in spirometry (48%). CT scan showed presence of honeycombing pattern in 66% of patients. Diagnosis detected usual interstitial pneumonia (UIP) in 50% while non-specific interstitial pneumonia (NSIP) in 22% patients. UIP involved patients’ lower lobe involvement (25 left and 24 right)