Background: Hepatitis C virus (HCV) is a blood borne virus that was first identified in 1989. HCV affects the liver, with some infected individuals developing cirrhosis of the liver and liver cancer. HCV is spread primarily by blood-to-blood contact associated with injection drug use, poorly sterilized medical equipment, needle stick injuries in healthcare, and transfusions. Methods: cross-sectional study, Study setting: Medicine department of Tertiary care center. Study population: The study population included all the cases of hepatitis C virus infection admitted in tertiary care center. Sample size: 30. Results: majority of cases were found in 31-45 years age group e.g. 16 cases (53.33%) followed by46-60 years age group 9 cases (30%), >60 years age group 3 cases (10%) and 2 cases found in 12-30 years age group. majority of cases were males e.g. 21 cases (70%) and 9 cases were females (30%). majority of cases had a history of injectable drug users e.g. 9 cases (30%) followed by 8 cases reported history of multiple sex partners (26.66%), 5 cases on dialysis required regular blood transfusion (16.67%), thalassemia found in 5 cases required regular blood transfusion (13.33%) and sickle cell anemia reported by 3 cases. There is statistically significant association between age and hepatitis C virus infection mortality. Conclusions: majority of cases were found in 31-45 years age group, most common in males, There is statistically significant association between age and hepatitis C virus infection mortality