Background: Respiratory distress (RD) is a challenging problem and is one of the most common causes of admission in neonatal intensive care unit (NICU). The common causes of RD in neonates includes transient tachypnea of the newborn (TTN), hyaline membrane disease (HMD), birth asphyxia, pneumonia, meconium aspiration syndrome (MAS), and other miscellaneous causes. Present study was aimed to clinical profile of neonates admitted in NICU with respiratory distress in a tertiary care hospital. Material and Methods: This study was prospective, observational study, conducted in neonates admitted to NICU with respiratory distress.