Aim: The aim of the present study was to assess clinical profile of ICU patients with sepsis. Methods: The present study was conducted at Dr. D.Y. Patil medical college and hospital and research center, Pimpri, Pune from August 2020 to September 2022 and 100 patients with sepsis from ICU were included. Results: Among the study population, 61.00% of them were 30 to 65 years, 30.00% of them were >65 years and 9.00% of them were <30 years. Among the study population, 66.00% of them were male, 34.00% of them were female. Among the study population with Present history, 90.00% of them had fever, 76.00% of them had Weakness, 57.00% of them had Abdominal Pain, 47.00% of them had Breathlessness, 29.00% of them had Burning Micturition, 27.00% of them had Altered Sensorium, 21.00% of them had Vomiting, 81.00% of them had Cough, 12.00% of them had Loose Stools, 8.00% of them had Chest Pain. Among the study population, 94.00% were febrile, 85.00% of them had pulse rate >90 bpm, 93.00% of them had respiration rate >20 cpm, 82.00% of them had SBP<=120mmHg, 81.00% of them had DBP <=80mmHg, 6.00% of them had mean arterial pressure <=65, 32.00% of them had SPO2 on RA <=90%.