Background: A secondary condition arising in India is a large number of post-COVID fungal infections. The present study was conducted to study CD4/CD8 among covid and post covid patients with fungal infection. Material & methods: The present prospective observational study was conducted among 50 patients admitted under COVID unit, IGIMS, Patna over a period of 6 months. 5ml of venous blood was drawn with aseptic precautions from patients. Then the serum was separated which was used for estimation of CD4+ and CD8+ count. Mean, standard deviation and confidence interval was calculated and the same represented by tables and graphs. Results: Mean CD4/CD8 ratio according to orbital/facial pain, orbital/facial edema, ptosis, proptosis, loss of vision was 1.46. Mean CD4/CD8 ratio according to nasal block, nasal discharge, orbital/facial pain, orbital/facial edema, ptosis, loss of vision was 1.74. The p value of CD4 count was 0.322, p value of CD8 count was 0.885 which was non-significant. The p value for CD4/CD8 ratio was 0.869 which was non-significant. According to final outcome among study subjects, the p value for was non significant for CD4, CD8 and CD4/CD8 ratio. According to final outcome if regressed among study subjects the p value was non significant for CD4, CD8 and CD4/CD8 ratio. According to severity of COVID symptoms among study subjects the p value was non significant for CD4, CD8 and CD4/CD8 ratio. According to species identified among study subjects, the p value was non significant for CD4, CD8 and CD4/CD8 ratio. According to primary management among study subjects, the p value was non significant for CD4, CD8 and CD4/CD8 ratio. Conclusion: The present study concluded that CD4/CD8 among covid and post covid patients with fungal infectionaccording to final outcome, According to final outcome if regressed, the p value was non significant. According to severity of COVID symptoms, According to species identified, According to primary management, the p value was non significant for CD4, CD8 and CD4/CD8 ratio.