Background: Dental caries is the most common chronic disease in children: it is about five times as common as asthma and seven times as common as hay fever. Dental caries may be considered as a disease of modern civilization. epilepsy affects 70 million people worldwide. Material and Methods: A cross-sectional study was undertaken on a total of 84 children aged 2–12 years, who were suffering from epilepsy receiving liquid oral medication for, ediatric anti-epileptic liquid medicaments which are most commonly usedin children for a prolonged period were obtained from local pharmacies after consulting pediatricians of Jamuhar Rohtas, Bihar. The physico-chemical analysis of endogenous pH, viscosity and sugar content of commonly prescribed ten anti- epileptic PLMs was done. Conclusions: Most of the antiepileptic PLMs showed cariogenic and erosive potential. The study highlights the need to reformulate the antiepileptic PLMs with sugar substitutes or without sugar content.