Alcohol being one of the most commonly used drug, whose consequences include changes of CBC. The main causes leading to changes of CBC (complete blood count) are, myelosuppression that is accompanying with slight reduction in all blood cells, blood loss from gastrointestinal tract, malnutrition etc. Alcoholics may suffer from moderate anemia, characterized by enlarged, structurally abnormal RBC’s. Multiple organs can be involved like Hepatobiliary system, cardiovascular system, Central nervous system, Haematopoietic system. Impact of alcohol on haematopoitic system divided into direct and indirect effects. This study is done to evaluate effect of alcoholism on blood indices. Total 50 moderate to severe alcoholics were included in study. . Blood indices which included Hemoglobin , RBC count , MCV, MCH,MCHC were estimated by cell counter. Results shows mean haemoglobin content and RBC count was less than normal values which tells that most of alcoholics are anemic . Mean values of MCV was more than normal range, which shows anemia seen in alcoholics was macrocytic. MCH and MCHC mean values are almost normal which tells that anemia in alcoholics was of macrocytic normochromic . Detection of hematological changes in alcoholics and giving psychiatric counseling and treatment for alcohol dependence will decrease the future complications