Introduction: The term suicide refers to the experience that one’s life is undeserved that starts with a thought and advances to the actual action to kill oneself or an obsession with self-destruction. This study aimed to construct a structural equation model of factors that affect suicidal ideation among undergraduate students. This study was conducted at 14 colleges at state universities in Jakarta, Indonesia. Method: A cross-sectional design was used in this study. A sample of 504 students was selected using a stratified random sampling method at 14 colleges. Data was analyzed with structural equation modelling testing. Results: Depression, anxiety, stress, and social support were significant factors that affected students’ suicidal ideation. Low social support was associated with increased suicidal ideation in college students. Depression, anxiety, and stress triggered suicidal ideation in students. Conclusion: Universities need to plan activities that can raise awareness and prevent students from experiencing depression, anxiety, and stress so that students can avoid suicidal ideation.