Stressful life events always create a disturbance in the normal life of any organism and thus is a threat to the homeostasis. This triggers off a physiological response which needs adaptation and response. Mild stress may subside over a period of time but if stress continues, it can cause damage and exacerbation of disease process. One such disease related to stress is ulcerative colitis. It was first described in mid-1800s. Ulcerative colitis is an idiopathic disease with chronic inflammation of the colonic mucosa. It commonly involves the rectum and can extend in a proximal and continuous fashion and other parts of the colon are affected. Though there is still a controversy over the role of psychosocial factors in the development and modulation of common gastrointestinal disorders, but researches do establish bidirectional interactions between the brain and gut, and that certain stressful life events frequently precede exacerbation of symptoms in gastrointestinal disorders.