Abstract Hindered phenolics are the compounds which will act as an antioxidant compared to the general phenolic compounds. Especially BHT compounds are shown here and which modifications will be responsible for the enhancing and reducing the efficacy of the phenolic compounds. These moieties are easily avaliable materials which found mostly in the foods, fruits and vegetables and also in several suppliments. The free radical oxidation of organic substrates is inhibited by phenols.and also involved in recovering from several pathophysiological conditions.In this review mentioned the several phenolic compounds which exhibits the effect of scavenging free radicals in the several pathophysiological conditions and daily life processes.