Spontaneous esophageal rupture is a rare clinical condition, occurs most often in the lateral, lower 1/3 of the esophagus and is associated with a mortality rate of 20–75%. As a result of these nonspecific findings, Spontaneous esophageal perforation is often misdiagnosed as an aortic emergency, pericarditis, myocardial infarction, pulmonary embolus, spontaneous pneumothorax, perforated peptic ulcer, or pancreatitis .We outline 6 cases of spontaneous esophageal perforation came to our institution and will discuss about their diagnosis ,required interventions ,complications and 2-year follow up.