ABSTRACT: Severe infections of the head and neck region may lead to life threatening complications. The infections of the odontogenic and upper airway origin may spread to facial planes and led to space infection. The morbidities and fatalities from these infections have reduced to a large extent with the advent of modern antibiotics. However early diagnosis plays an important role in preventing the lethal complications. The aim of this review article is to discuss the etiology, manifestations and management of space infections.