Abstract: Sjogren’s syndrome (SS) is a slowly progressive chronic autoimmune disease characterized bychronic inflammation of the exocrine glands. Xerostomia, Keratoconjuctivitis sicca and the B-lymphocytes hyperactivity are the characteristic features of the syndrome.Sjogren's syndrome (SS) also called as “Mikulicz disease” and “Sicca syndrome”. Lacrimal and salivary glands are most affected, which leading to mouth dryness and eye dryness.Sjogren syndrome can exist by itself known as primary Sjogren syndrome or associated with another disorders such as systemic sclerosis, rheumatoid arthritis, primary biliary cirrhosis or Hashimoto thyroiditis (associated secondary Sjogren syndrome).