Introduction: Several randomized clinical trials (RCTs) have assessed the effectiveness of lifting the maxillary sinuses. Our study did additional research, in which it was witnessed that bone neoformation and implant osseointegration after sinus lifting with/ without grafting material was possible. In the current study we aimed to conduct a systematic review and meta-analysis on the maxillary sinus lift up and implant placement. Methodology: An electronic search was performed in PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, Embase, till 2020. We considered prospective and retrospective cohort studies, controlled clinical trials, and randomized clinical trials. The search and selection process yielded 18 studies, published between 2005 and 2020. A meta- analysis was conducted only for experimental studies comparing sinus floor elevation with and without grafting material; results were expressed as the standardized mean difference (SMD) or risk ratio (RR) with the 95% confidence interval (CI). Results: An average gain in bone height of 4.7 mm over an average 39.4 month period was observed in the sinus elevated without grafting material. Regarding implants, there was a cumulative average survival rate of 97%. On meta-analysis, bone gain (P = 0.98) and implant survival (P = 0.13) did not differ significantly between sinuses lifted with or without grafting material, with a SMD of 0.01 (95% CI —0.42 to 0.44) and with a RR of 0.55 (95% CI 0.26 to 1.19), respectively. Conclusion: The results of this systematic review suggest that the technique of maxillary sinus lifting with immediate implant placement has a high success rate, with an average bone height increase of 4.7 mm over an average follow-up period of 39.4 months. After conducting the meta-analysis, no significant difference was found in the amount of bone formation or survival of lifted sinus implants between sinuses lifted with or without grafting material.