Background: Gynecological malignancies account for three fourth of the female patients who present with malignant ascites. Similarly in males half of the patients with malignant cells in their peritoneal washings have malignancy involving GI tract. This study was conducted to assess free malignant cells in peritoneal cavity with varied clinicopathological profile of patients with gastrointestinal malignancies and its correlation with stage of disease. Materials and Methods: Patients with Gastrointestinal malignancy presenting to surgical OPD during study year were assessed for clinic- pathological stage and malignant cytology. Correlation between presence of positive malignant cytology and clinicopathological stage was assessed. Results: Out of total 34 patients with malignancies involving colorectal, gastric, esophageal and pancreas, 9 had been found to be having free malignant cells in peritoneal cavity. Advanced stage of the disease with worse clinic-pathological profile had more propensity of free malignant cells in peritoneal cavity Conclusion: Significant correlation was found between clinicopathological stage and presence of positive malignant cytology. However, we failed to demonstrate any correlation between degree of differentiation of tumor and positive malignant cells in peritoneal cavity INTRODUCTION Malignant ascites is most common due to colorectal, gastric, pancreatic and uterine, ovarian cancers. Seventy five percent of women with malignant ascites i.e., presence of malignant cells in ascitic fluid have malignancy of ovary, uterus, or cervix; while only ten percent have malignancy of GI tract.1 Whereas in men with malignant ascites more than 50% cases have malignancies of GI tract. Presence of malignant cells in ascitic fluid of patients help in arriving at diagnosis of malignancy and selecting the patients for appropriate treatment modalities.