Aims: The present study was designed to assess LAD and LADi as a predictive marker for Acute Ischemic Stroke and to analyse their association in patients with AF in Acute Ischemic Stroke patients. Materials & methods: This study was conducted on 50 patients with acute ischemic stroke and 50 patients without stroke who attended outdoor department or who were admitted in Medicine Department of Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar. The patients were divided into two groups (Group A and B) as follows: Group A includes 50 Patients with acute ischemic stroke, and Group B includes Age and sex matched 50 patients without stroke. Left atrial diameter (LAD) was measured using Two-dimensional echocardiography from the posterior aortic wall to the posterior left atrial wall according to a leading edge to leading edge convention in the parasternal long-axis view at the end-ventricular systole (i.e., just before the mitral valve opening). Indexed left atrial diameter (LADi) was calculated by dividing Left atrial diameter with body surface area (BSA). The data was collected systematically and analysed using Microsoft excel sheet and statistical package for social science version 21.0 (SPSS, Chicago, IL, USA).