Background: Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections account for a substantial proportion of liver diseases worldwide. These viruses are responsible for liver damages ranging from minor disorders to liver cirrhosis and hepatocellular carcinoma (HCC). Approximately 7% of the world’s population (350 million people) are infected with HBV and 3% (170million people) with HCV. Aim & Objectives: To study Prevalence of Hepatitis B & Hepatitis C viruses infections in Chronic liver disease patients . Materials & Methods: A total of 100 Cases of CLD attending Gastroenterology department were included in the study during the period of January 2015 – June 2016. Demographic data and clinical findings were recorded using a structured proforma. All the samples were screened for HBsAg detection( ERBALISA SEN HBsAg)& anti HCV antibodies detection by ELISA (HCV MICROLISA) following the kit manufacturer’s instructions.Results: Out of 100 CLD Patients, 81 (81%) were Males & 19 (19%) were Females. Male to Female ratio of the total chronic liver disease patients 4.2:1. HBsAg was found positive in 10 patients of which 9 were Males & 1 was female. Anti-HCV antibodies was found Reactive in 4 cases of which , 3 were Males & 1 was Female. 40-60 Yrs of age group were commonly affected with HBV & HCV infections. Males were more commonly affected than Females with both HBV & HCV infections. Conclusion: In Present study, Hepatitis B infection was more common than Hepatitis C infection in chronic liver disease patients. Coinfection with HBV and HCV was not found . Males were more commonly affected . Most common age group affected was 40-60 Yrs.